منابع مشابه
Expression of the immunoglobulin VH gene 51p1 is proportional to its germline gene copy number.
51p1 is an immunoglobulin VH gene that is frequently expressed in B cell chronic lymphocytic leukemia and early in B cell ontogeny. The 51p1 gene locus is highly polymorphic, consisting of 13 alleles that can be classified as being either 51p1-related or hy1263-related, based on distinctive sequence motifs in the second complementarity determining region. Two of the 51p1-related genes usually o...
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Gene therapy has developed as a method of approach to the treatment of human diseases based on the transfer of genetic material to the cells of an individual. Normally, the aim of this transfer of genetic material is to re-establish a cellular function that has been abolished or is defective, to introduce a new function or to interfere with an existing function. Thus, the different gene therapy...
متن کاملDisplaced agendas: current regulatory strategies for germline gene therapy.
Recent developments in biotechnology are radically affecting the nature of reproduction and the manner in which we approach disease. In particular, germline gene therapy, or the insertion of genetic material into cells while they are developing and dividing, offers the promise of eradicating genetic defects in humans during embryonic development. In this article, the authors argue that the soci...
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From its earliest conception, gene therapy held the promise of correcting inherited diseases by inserting a normal copy of the relevant gene into somatic cells.1 Common monogenic diseases of blood cells, such as sickle cell disease or β-thalassemia, were originally considered important candidates for gene therapy because they were well understood at the molecular level and because the target ce...
متن کاملGene therapy finds its niche
121 Jesse Gelsinger in 1999 from vector-associated toxicity was a stark exception (Box 1). The episode, as the headline above one editorial at the time put it, marked “a loss of innocence” for the field3. It also primed critics for any subsequent problems—which did not take long to emerge. Shortly after Gelsinger’s death, five cases of leukemia in SCID-X1 children receiving gene therapy treatme...
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ژورنال
عنوان ژورنال: Molecular Human Reproduction
سال: 1996
ISSN: 1360-9947,1460-2407
DOI: 10.1093/molehr/2.2.75